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Highlights

Sodium Valproate
This medication is used to treat seizure disorders. It works by restoring the balance of certain natural substances (neurotransmitters) in the brain. This drug may also be used for the prevention of migraine headaches and treatment of certain psychiatric conditions (e.g., manic phase of bipolar disorder, schizophrenia). This medication has rarely caused serious (sometimes fatal) liver problems. Children less than 2 years old are more likely to develop severe liver problems, especially if they have metabolic problems, severe seizures with mental retardation, brain disease (organic) or if they take more than one drug for seizures. If valproate sodium is being used in patients with these conditions, then it should not be taken with additional anti-seizure medications. Liver function tests should be performed before and during treatment. Early signs of serious liver problems include vomiting, unusual tiredness, swelling of the face or loss of seizure control in patients with seizure disorder. This medication has rarely caused severe (sometimes fatal) disease of the pancreas (pancreatitis). This problem may occur at any time during therapy and may worsen quickly.

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